![]() ![]() We excluded patients who had a history of allergy to systemic opioids, substance use disorder, coagulopathy, chronic opioid use, sleep apnea, and analgesic use within 24 h. We enrolled colon cancer patients aged 20 to 75 years who were scheduled for elective laparoscopic colectomy under general anesthesia. This randomized, double-blind study was conducted between November 2013 and October 2014. This study received approval from the ethics committee of Kyungpook National University Medical Center (ref: KNUMC_13-1048) and was registered with CRiS (Clinical Research Information Service,, ref: KCT0000984, 2013.10.18). Postoperative fatigue and side effects were analyzed as secondary outcomes. ![]() TO ELIMINATE THE OPIATE VOL 2 PDF TRIALTherefore, we designed a randomized placebo-controlled trial to examine the effect of high dose vitamin C (50 mg/kg) on postoperative opiate consumption and pain scores in colon cancer patients during the first 24 h after laparoscopic colectomy. Recent studies have shown that vitamin C supplementation might be a useful adjunct to pain management without significant side effects. Vitamin C (ascorbic acid) is a water-soluble vitamin that has antioxidant, neuroprotective, and neuromodulating effects. Recently, nonopioid analgesic alternatives have been introduced with the aim of improving pain management and limiting opioid-related side effects. Opioids, which are still the most widely used class of analgesics in postoperative pain management, can increase the risk of postoperative nausea and vomiting (PONV) and can delay postsurgical recovery of gastrointestinal mobility. Inadequate postoperative analgesia can lead to adverse events such as pneumonia, myocardial infarction, insomnia, and depression, thereby increasing morbidity and mortality and diminishing quality of life and patient satisfaction. Laparoscopic surgical approaches might reduce postoperative pain associated with colorectal surgery, but postoperative pain management remains a complex challenge. The importance of providing adequate pain control during recovery from surgery cannot be overemphasized. Additional research needed to examine whether higher doses of vitamin C and longer infusion times can amplify these effects. This study shows high dose vitamin C infusion decreased postoperative pain during the first 24 h and reduced morphine consumption in the early postoperative period. There was no significant difference between groups in side effects, fatigue score, or pain score during cough. Patients who received vitamin C had higher plasma concentrations of vitamin C at the end of surgery, significantly lower morphine consumption at the 2 h after end of surgery, and significantly lower pain scores at rest during first 24 h postoperatively. There were 97 patients included in the analysis. Morphine consumption and scores of pain were assessed at 2, 6, and 24 h after completion of surgery. A total of 100 patients were enrolled and allocated to receive 50 mg/kg vitamin C or placebo by intravenous infusion immediately after induction of anesthesia. Therefore, we designed this study to assess the effect of intravenous vitamin C on opiate consumption and pain in patients undergoing laparoscopic colectomy. ![]() Recently, it showed antinociceptive effect as a result of the antioxidant properties. Vitamin C has antioxidant, neuroprotective, and neuromodulating effects. ![]()
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